Association of Mitochondrial DNA Haplogroups with Exceptional Longevity in a Chinese Population
نویسندگان
چکیده
BACKGROUND Longevity is a multifactorial trait with a genetic contribution, and mitochondrial DNA (mtDNA) polymorphisms were found to be involved in the phenomenon of longevity. METHODOLOGY/PRINCIPAL FINDINGS To explore the effects of mtDNA haplogroups on the prevalence of extreme longevity (EL), a population based case-control study was conducted in Rugao--a prefecture city in Jiangsu, China. Case subjects include 463 individuals aged > or = 95 yr (EL group). Control subjects include 926 individuals aged 60-69 years (elderly group) and 463 individuals aged 40-49 years (middle-aged group) randomly recruited from Rugao. We observed significant reduction of M9 haplogroups in longevity subjects (0.2%) when compared with both elderly subjects (2.2%) and middle-aged subjects (1.7%). Linear-by-linear association test revealed a significant decreasing trend of N9 frequency from middle-aged subjects (8.6%), elderly subjects (7.2%) and longevity subjects (4.8%) (p = 0.018). In subsequent analysis stratified by gender, linear-by-linear association test revealed a significant increasing trend of D4 frequency from middle-aged subjects (15.8%), elderly subjects (16.4%) and longevity subjects (21.7%) in females (p = 0.025). Conversely, a significant decreasing trend of B4a frequency was observed from middle-aged subjects (4.2%), elderly subjects (3.8%) and longevity subjects (1.7%) in females (p = 0.045). CONCLUSIONS Our observations support the association of mitochondrial DNA haplogroups with exceptional longevity in a Chinese population.
منابع مشابه
Molecular Diversity of Mitochondrial DNA in Iranian Azeri Ethnicities vis-Ã -vis Other Azeris in Asia
In order to investigate the molecular diversity of mtDNA in Azeri population, 133 Azeri subjects inhabitingdifferent regions of Azerbaijan (Iran) were selected. Blood samples were taken from these subjects formtDNA extraction. The extracted mtDNA samples were then studied by the PCR-RFLP method.Fourteen haplogroups were characterized from which 82% were identified as European ...
متن کاملRole of Mitochondria in Ataxia-Telangiectasia: Investigation of Mitochondrial Deletions and Haplogroups
Ataxia-Telangiectasia (AT) is a rare human neurodegenerative autosomal recessive multisystem disease that is characterized by a wide range of features including, progressive cerebellar ataxia with onset during infancy, occulocutaneous telangiectasia, susceptibility to neoplasia, occulomotor disturbances, chromosomal instability and growth and developmental abnormalities. Mitochondrial DNA (mtDN...
متن کاملThe steroid biotransformation genes in genomes of mycobacteria
The sequence of the human mitochondrial genome was established almost 25 years ago and has been used in analysis of human population migrations, forensic medicine, longevity studies and in investigation of the causes of mitochondrial diseases.It is a small compact genome of 16.5 kb containing information about 13 protens, 2 rRNAs and 22 tRNAs.There are many variants (haplogroups) of the human m...
متن کاملThe Creation of Cybrids Harboring Mitochondrial Haplogroups in the Taiwanese Population of Ethnic Chinese Background: An Extensive In Vitro Tool for the Study of Mitochondrial Genomic Variations
Mitochondrial DNA (mtDNA) haplogroups may contribute to the development of aging-related diseases. A reliable in vitro cellular system for investigating the physiologic significance of mtDNA haplogroups is essential. This study aims to construct and characterize a series of cybrid cell lines harboring variant mtDNA haplogroups collected from healthy Taiwanese volunteers. Cybrid cells harboring ...
متن کاملA mitochondrial haplogroup is associated with decreased longevity in a historic new world population.
Interest in mitochondrial influences on extended longevity has been mounting, as evidenced by a growing literature. Such work has demonstrated that some haplogroups are associated with increased longevity and that such associations are population specific. Most previous work, however, suffers from the methodological shortcoming that long-lived individuals are compared with "controls" who are bo...
متن کامل